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WELCOME TO THE MAHMOUDI LAB

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“My lab investigates the molecular mechanisms in disease. We use insights from our fundamental research to address clinical challenges in human diseases, including HIV infection, liver and bladder cancer. Specifically, the research aims of my group are to decipher the precise molecular and functional consequence of chromatin mediated gene regulation in pathogenesis resulting from viral infection and/or tumorigenesis and to develop pharmacological approaches to modulate this process.”

Tokameh Mahmoudi

LATEST NEWS

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JUST PUBLISHED

A 3D organoid platform that supports liver-stage P.falciparum infection can be used to identify intrahepatic antimalarial drugs

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JUST PUBLISHED

NPEPPS Is a Druggable Driver of Platinum Resistance.

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JUST PUBLISHED

Hepatitis C virus infects and perturbs liver stem cells.

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JUST PUBLISHED

PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency

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SOON TO BE PUBLISHED

SQuHIVLa: A novel assay for Specific Quantification of inducible HIV-1 reservoir by LAMP

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EXCITING FINDINGS AT MAHMOUDI LAB

Non–muscle-invasive bladder cancer molecular subtypes predict differential response to intravesical Bacillus Calmette-Guérin.

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NEW RESULTS

The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy

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JUST PUBLISHED

Catchet-MS identifies IKZF1-targeting thalidomide analogues as novel HIV-1 latency reversal agents

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JUST PUBLISHED

DEAD-ly Affairs: The Roles of DEAD-Box Proteins on HIV-1 Viral RNA Metabolism

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JUST PUBLISHED

HibeRNAtion: HIV-1 RNA Metabolism and Viral Latency

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JUST PUBLISHED

A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency

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JUST PUBLISHED

Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma. ELife 2021

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JUST PUBLISHED

Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir. Nat Comm 2021

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IN THE MEDIA

Researchers from the Netherlands find a way to incite HIV cells to self-destruct. First step to cure?

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AMAZING ERASMUS

All cells in our body have the same genetic material. Why then does one cell become a liver cell and the other skin cell or brain cell?

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